Inflammation in response to viral infection begins with the recognition of a virus by toll-like receptors (TLRs), retinoic-acid-inducible gene-I (RIG-I)-like receptors (RLRs), nucleotide oligomerization domain (NOD)-like receptors (NLRs), mitochondrial antiviral-signaling protein (MAVS), and cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING), all components of the innate immune response [15]. The gene discussed is MAVS; the disease is viral infectious disease.