Conversely, inhibition of BRAF signaling using either a broad-spectrum Raf inhibitor or by selective knockdown of BRAFV600E expression by RNA interference in human melanoma cells leads to decreased IKK activity and β-Trcp expression, stabilization of IκB, inhibition of NF-kB transcriptional activity and sensitization of these cells to apoptosis [14]. Here, BRAF is linked to melanoma.