Food intake with FOS, GOS, oligofructose, inulin, and polyunsaturated fatty acids regulate total cholesterol (TC), LDL-C, and CRP levels, exhibit anti-obesity effects, and reduce body weight and body fat and IL-6 serum levels in overweight or obese patients; even synbiotics (GOS + FOS + Bifidobacterium breve) have prevented diet-induced obesity in adult mice when administered in early life [81]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.