Some authors report that animal studies with mice, combining probiotics and/or prebiotics with antidiabetic medications showed an improvement in glycemic control and insulin sensitivity; for example, Bacteroides fragilis, Akkermansia muciniphila, Lactiplantibacillus plantarum, and Lacticaseibacillus casei induce IL-10, which has been shown to improve both insulin resistance and glucose metabolism [97]. Here, INS is linked to Insulin resistance.