As already happened in the advanced setting, for oncogene-addicted disease, experimentations have focused on Epidermal Growth Factor Receptor (EGFR) gene mutations (EGFRm) and Anaplastic Lymphoma Kinase (ALK) rearrangements (ALKr), the most commonly detected in NSCLC pts. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.