Tsuruya et al. (2003) highlighted protection attributed to TNFR1 deficiency, but Ramesh and Reeves (2003) contrastingly reported that TNFR2 deficiency provided a greater degree of resistance to toxicity despite the upregulation of both receptors in murine models of CIN [133,134,135]. The gene discussed is TNFRSF1A; the disease is cervical squamous intraepithelial neoplasia.