Osimertinib showed a superior median progression-free survival (PFS) of 17.2 months compared to 8.5 months for gefitinib or erlotinib in naïve NSCLC patients, leading to its approval by the FDA as a first-line treatment for patients with classical EGFR mutations in 2018 based on Phase III FLAURA clinical trial [53]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.