In addition, StARD3 has been linked to cholesterol overload in mitochondria in NPC1 deficiency [159,160], which supported roles for StARD3 in LE/Lys-Chol transport to mitochondria for steroidogenesis, mitochondrial well-being and energy production, all anti-apoptotic properties in cancer settings [161,162]. Here, STARD3 is linked to cancer.