NPC1 and cancer: Most important here, NPC1-dependent and -independent cholesterol transfer mechanisms across MCS between LE/Lys and the ER involve members of the StARD and ORP families, Rab7 and their regulators and effectors, as well as the scaffolding protein annexin AnxA6 [9,10,11,12,145,146], all of which with links to cancer that will be described in more detail in the following sections.