TNF-α can directly regulate the expression and function of Nav1.6 by epigenetically upregulating Nav1.6 expression via the signal transducer and activator of transcription-3 (STAT3) pathway, which promotes the trafficking of Nav1.6 to the membrane of neurons in DRG, an essential step in mediating neuronal excitability and repetitive firing, thus contributing to neuropathic pain [84,94]. Here, SCN8A is linked to neuropathic pain.