A recent study showed that impaired death (necroptosis) and/or repopulation of microglia underpin their dysregulated activation in neurological diseases [53]; in addition, necroptosis can be triggered by many death receptors, including Fas, TRAIL and TNF receptors, mainly through the signalling pathway induced via the binding of TNF-α to TNF receptor 1 (TNFR1) [54]. The gene discussed is TNFRSF1A; the disease is nervous system disorder.