In accordance with this, the HR-HPVs, which are proven to be the main motive of cervical cancer, down-regulate cellular tumor suppressors (pRB and p53) and epidermal growth factor receptors (EGFR), through HPV oncoproteins (E5, E6, and E7) integrating into the cellular DNA and stimulating some inflammation pathways. This evidence concerns the gene ARHGEF15 and cervical carcinoma.