Trah et al. [84] showed that the treatment of WT-CLS1 and SK-NEP1 nephroblastoma cells with LCA increased the levels of the G protein-coupled bile acid receptor (TGR5) without affecting the expression of NRF2, a downstream regulatory protein of the TGR5 pathway, and caused cytotoxicity due to caspase-3 and -7 activation. The gene discussed is GPBAR1; the disease is Nephroblastoma.