STAT4 and rheumatoid arthritis: Although, LGALS1 has not been described as a risk factor locus for RA development, previous studies from our group have shown that RA severity can be modulated by genetic variants in loci associated with RA development, such as rs7574865 in STAT4 [15], or in other loci not related with RA development, such as rs688136 in VIP [20] or rs4780355 in SOCS1 [21].