SHANK3 and schizophrenia: For example, mice with overexpression of SH3 and multiple ankyrin repeat domains 3 (SHANK3), a gene associated with schizophrenia pathogenesis [5,6], exhibited mania-like behaviours [5,7] and enriched ribosome-related genes as identified in The Kyoto Encyclopedia of Genes and Genomes (KEGG) gene library [8].