CALHM6 and Alzheimer disease: Regarding the BV2 cell line, our results showed that several of the inflammation-modulated genes of our set are involved in neurodegeneration: Ly6a, Cxcl9, Serpine3G, Fam26f, Gbp2, Slamf8, and Adm. The Ly6a-encoded protein is an acetylcholine receptor binding, and it was upregulated in a mouse model of sleep deprivation and AD [34].