Two of them are Cxcl9 and Cxcl11, which are involved in Th1-type response, correlating with T-cell infiltration; the comprehension of CXCR3 (C-X-C Motif Chemokine Receptor 3)/CXCL9′s binding mechanism of action is considered crucial for the treatment of central nervous system diseases [41]. The gene discussed is CXCR3; the disease is central nervous system disorder.