BHLHE22 expression was significantly, positively correlated with immune cells infiltrate in the tumor microenvironment, including B cells, M1 macrophage, regulatory T cells, myeloid dendritic cells, resting myeloid dendritic cells, CD8+ T cells, CD4+ T cells, and activated memory CD4+ T cells, and negatively correlated with activated myeloid dendritic cells (Figure 6b and Figure S4a). This evidence concerns the gene CD8A and neoplasm.