Interestingly, NCKX2, the isoform most expressed in the brain among the members of the family of the K+-dependent Na+/Ca2+ exchangers (NCKX), exerts a relevant role during cerebral ischemia since both its knocking-down and its knocking-out dramatically increase the extent of the ischemic lesion in rats and mice subjected to brain ischemia. This evidence concerns the gene SLC24A2 and brain ischemia.