By contrast, the observation that preconditioning in the striatum does not induce an increased expression but rather prevents the dramatic NCKX2 downregulation occurring after cerebral ischemia might be explained by the fact that the striatum represents a brain region strongly affected by the ischemic damage after tMCAO and the only brain region damaged in animals exposed to preconditioning followed by tMCAO. This evidence concerns the gene SLC24A2 and brain ischemia.