There were considerable differences in the transcripts correlated with disease indices with several known AD genes (e.g., APP, EED, CNTNAP5, TREM2, GFAP) positively correlated with disease markers in one group and negatively correlated in the other (EED and CNTNAP5 had disparate correlations in the ROSMAP data as well). This evidence concerns the gene GFAP and Alzheimer disease.