There were considerable differences in the transcripts correlated with disease indices with several known AD genes (e.g., APP, EED, CNTNAP5, TREM2, GFAP) positively correlated with disease markers in one group and negatively correlated in the other (EED and CNTNAP5 had disparate correlations in the ROSMAP data as well). Here, CNTNAP5 is linked to Alzheimer disease.