Seven out of ten pairs (miR-421 and ABCB1, CD274, MYD88, and STAT3 and miR-744 and BCL2, PPARGC1A and TLR4) presented disruption in their regulation patterns, changing from no correlation or positive correlation in tumors of patients with the localized disease to a negative correlation in metastatic disease (Figure S5). This evidence concerns the gene TLR4 and metastatic neoplasm.