Functionally, taking advantage of two invaluable ligand tools, the plant toxins capsaicin and resiniferatoxin (RTX), a potent phytotoxin activator discovered from the plants Euphorbia resinifera and Einhorbia poissonii, researchers have achieved the first cloning and characterization of TRPV1, which brought insight into the function of TRPV1 in itch, cancer, and weight loss [44]. This evidence concerns the gene TRPV1 and cancer.