An in vitro study on the BRAFV600E A375 and the NRASQ61R SK-MEL-2 melanoma cell lines confirms that COX-2 expression positively modulates the expression of programmed death-ligand 1 (PD-L1)-trans-membrane protein found on the antigen presenting cells (APCs) as well as tumor cells. The gene discussed is CD274; the disease is melanoma.