LEP and obesity due to melanocortin 4 receptor deficiency: In the proinflammatory environments of obesity, the upregulation of proinflammatory adipokines (e.g., leptin, chemerin, resistin, visfatin, vaspin, kallistatin, tenascin C, osteopontin, calprotectin, interleukin-1, interleukin-6, interleukin-8, interleukin-32-alpha, and tumor necrosis factor-alpha) and the downregulation of anti-inflammatory adipokines (e.g., adiponectin, omentin, fibroblast growth factor 21, lipocalin 2, secreted frizzled-related protein 5, and interleukin-10) are reported [38,39,40].