OXTR and schizophrenia: In addition, single-nucleotide polymorphisms of the oxytocin receptor gene (OXTR) are also associated with a risk of schizophrenia [225], and a relationship with clinical symptomatology in schizophrenia, including general psychopathology [226], negative symptoms [224], social cognition [227,228], and the treatment response with antipsychotics for positive symptoms [226], has been more clearly elucidated.