With regard to FGFR expression, a previous study showed that loss of FGFR1 and FGFR2 in keratinocytes results in a defect in wound healing similar to the abnormality seen in chronic human skin ulcers, and this phenotype is characterized by impaired severe re-epithelialization combined with decreased wound contraction [17]. Here, FGFR1 is linked to Skin ulcer.