ENG and Stroke: Of note stimulation of our cell model with IL-1β, shown to be upregulated in experimental and human stroke [20] and previously described as effectively inducing the shedding processes in various endothelial cells [21,22], revealed a significant decrease of −43% [0.57 (0.39–0.75)] in membrane-bound ENG protein levels after 24 h (Figure 1E,F).