Dysregulated inflammasome activity has been linked to uncontrolled inflammation; in fact, a gain of the function variants of NLRP3 in the MS peripheral blood monocytes of MS patients can represent a risk related to MS severity, due to significantly increased production of the proinflammatory cytokine IL-1β [74,75,76]. This evidence concerns the gene NLRP3 and myeloid sarcoma.