Interestingly, hypermethylation of the CpG sites at risk-genes’ promotors, such as HLADRB1, IL2RA, IL7, IL7R, IL12RB1, IL12A, TNFRSF1A, and STAT3, has been related to MS pathogenesis [77,81,82]. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.