Mice with pancreatic tumors had elevated percentages of gMDSC (CD11b+Ly6G+Ly6C+/−, p = 0.0005; Figure 1B), cDC1 (CD8+CD11b−CD103−CD24+, p = 0.0022, Figure 1C), migratory cDC2 (CD8−CD11b+CD103+CD24++, p = 0.0154; Figure 1D), and pDC (CD11b−CD11c+Ly6C+CD317+, p = 0.0079; Figure 1E), populations and reductions in Langerhans DC (MHC class II+CD11b+CD11c+Ly6C−DC-sign+, p = 0.0011; Figure 1F) populations compared to mice without tumors. The gene discussed is CD8A; the disease is pancreatic neoplasm.