Very recently, the capability of LAM cells to modulate the LAM-Associated fibroblasts (LAFs) phenotype was demonstrated in an in vitro model of LAM microtissues, where non-expressing-tuberin LAM cells cause the increased expression of the Fibroblasts Growth Factor 7 protein, which acts as a chemotactic and mitogen factor for epithelial cells [18]. Here, TSC2 is linked to lymphangioleiomyomatosis.