Indeed, even if IL-8 has a clear role as a SASP molecule, its secretion by fibroblasts, alveolar macrophages, and alveolar cells and its involvement in neutrophil migration and infiltration in lungs suggest a more complex physiological implication, making the deregulation of IL-8 secretion responsible for pathological processes, i.e., in IPF [25], acute respiratory distress syndrome [26], and chronic obstructive pulmonary disease [39]. The gene discussed is CXCL8; the disease is acute respiratory distress syndrome.