HMOX1 and age-related macular degeneration: A recent study has reported that RPE degeneration, a major pathologic process of AMD, is associated with ferroptosis via HO-1 induction and ferrous ion accumulation in the sodium iodate-induced oxidative stress model, and this process is inhibited by siRNA-mediated HO-1 knockdown or administration of the HO-1 inhibitor ZnPP or the iron chelator, deferoxamine [108].