They include members of different family receptor groups, but we will focus on those receptors that are responsible for immunosurveillance of tumour-like NKG2D, CD16, natural cytotoxicity receptors (NCR), DNAX accessory molecule-1 (DNAM-1), CD224/natural killer cell receptor 2B4, NK-T-B antigen (NTB-A), CD161/NKRP1A, and CD319/CS1 (Figure 1) [81,82,83,84]. This evidence concerns the gene KLRK1 and neoplasm.