At this point, three additional NK cell subsets can be identified: CD56dimCD16-, CD56bright tCD16dim, and CD56-CD16+; the last of which is the only NK cell subset negative for CD56 and has been reported to expand in chronic HIV infection, malaria, endemic Burkitt lymphoma, and prolonged SARS-CoV-2 infection [9,12,13]. This evidence concerns the gene NCAM1 and HIV infectious disease.