Considering the complex regulation of NK cell responses, we will focus only on selected inhibitory receptors that are known to suppress NK cells functions in tumour, such as KIR2DL1–3, KIR3DL1–2, NKG2A/CD94, TIGIT, PD-1, LAG-3, and Tim-3 (Figure 1) [37,38,39,40,41]. Here, KIR3DL1 is linked to neoplasm.