For instance, upon infection of differentiated human nasal epithelial cells (hNECs) and primary human nasal epithelial progenitor cells with human rhinovirus (HRVs), the epithelial NLRP3 inflammasomes mediated the hNEC pyroptosis via DDX33/DDX58–NLRP3–caspase-1–GSDMD axis. The gene discussed is CASP1; the disease is infection.