The involvement of the microbiota in the development of uveitis is based, fundamentally, on the EAU model induced by active immunization with external retinal antigen “inter-photoreceptor retinoid-binding protein” (IRBP) [41,54] and the spontaneous EAU model of a transgenic mouse that expresses the self-reactive T cell receptor (TCR) of [35,55]. Here, RBP3 is linked to uveitis.