For example, circSnx5 can regulate dendritic cells activation and function through the miR-544/SOCS1 axis and inhibit nuclear translocation of PU.1 [111], circ-0007456 is significantly down-regulated in tumor tissues, and circ-0007456 regulates the expression of ICAM-1 in HCC by sponging miR-6852-3p, thus regulating the susceptibility of HCC tumor cells to NK cells [112]. The gene discussed is SPI1; the disease is hepatocellular carcinoma.