The researchers found that circ-0001666 acts as a sponge of miR-1251, the circRNA-associated ceRNA network further up-regulates SOX4 [93], and circRTN4 regulates the expression of Slug, Snai1, Twist, Zeb1, and N-cadherin in the EMT pathway by interacting with tumor suppressor miR-497-5p [94]. The gene discussed is ZEB1; the disease is neoplasm.