SNAI1 and neoplasm: In the serum and urine exosomes of bladder cancer, circPRMT5 sponges miR-30c through the snail1/E-cadherin pathway to enhance the EMT process, while circ-PDE8A, from hepatic metastatic PDAC cells, acts as a sponge of miR-338 to up-regulate MACC1 and then increases the invasive growth of PDAC cells, thus affecting the tumor progression [120].