Circ_0067934 can act as a competing endogenous RNA to facilitate NSCLC progression by regulating the miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway [34], circ_0000567/miR-421/TMEM100 axis can promote the migration and invasion of lung adenocarcinoma and is associated with cancer prognosis [35], and circ_0020123 interacts with miR-1283 as a ceRNA to regulate PDZD8 expression, thus promoting the proliferation and migration of cancer cells [36]. Here, TMEM100 is linked to cancer.