Further, circVRK1 upregulates PTEN by acting as a molecular sponge of miR-624-3p, decreasing the activity of PI3K/AKT signaling pathway, and further inhibits the proliferation, migration, and EMT of EC cells and reversing the radio-resistance [90], and downregulation of circ_0001273 can inhibit the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR-622/SLC1A5 signaling axis, indicating high expression of circ_0001273 contributes to EC progression via modulating the miR-622/SLC1A5 signaling axis [91]. This evidence concerns the gene SLC1A5 and esophageal cancer.