Hsa-circ-0110102, as a cancer-causing circRNA, inhibits the expression of CCL2 in HCC cells through the sponge effect of miR-580-5p, CCL2 further activates the COX-2/PGE2 pathway in macrophages in a FOXO1-dependent manner, and promotes the progress of hepatocellular carcinoma [114]. This evidence concerns the gene CCL2 and hepatocellular carcinoma.