Hsa_circ_0006732 regulates colorectal cancer cell proliferation, invasion, and EMT by miR-127-5p/RAB3D axis [49], circ_0085315 can promote cell proliferation, invasion, and migration in colon cancer through miR-1200/MAP3K1 signaling pathway [50], hsa_circ_0007843 can act as a miR-518c-5p sponge to regulate the migration and invasion of colon cancer SW480 cells [51], and circular RNA hsa_circ_0008285 inhibits cell proliferation and migration via the miR-382-5p/PTEN axis. Here, MAP3K1 is linked to colonic neoplasm.