Indeed, IH induces various mechanisms, such as elevation of oxidative stress, activation of Hypoxia-Inducible Factor-1 (HIF-1) and its target genes, such as VEGF [5,6], low grade chronic inflammation and sympathetic activation that, in turn, lead to endothelial dysfunction, hypertension, vascular wall thickening and degradation of the elastic fibers [7,8,9,10,11] and atherosclerosis [3,12,13]. The gene discussed is VEGFA; the disease is atherosclerosis.