SPP1 and metabolic dysfunction-associated steatohepatitis: Furthermore, the exaggerated fibrosis development seen in hepatocyte-specific HuR deficient mice after feeding with a NASH-inducing diet was partially reduced by treatment with an OPN neutralizing antibody, therefore suggesting that HuR negatively regulates the JAG1-Notch-OPN axis in hepatocytes, thereby protecting against fibrosis [98].