During NASH, the Toll-like receptor 4 (TLR4)-nuclear factor kappa B (NF-κB) signaling pathway is activated in pericentral hepatocytes, which are exposed to increased levels of gut-derived LPS; this results in increased Jagged1 (JAG1) expression on the cell surface [96]. Here, TLR4 is linked to metabolic dysfunction-associated steatohepatitis.