Frizzled 4 and 7 (Fzd4 and Fzd7) receptors and low-density lipoprotein (LDL) receptor-related protein 5 and 6 (LRP5 LRP6) are significantly increased in pathological neovascularization in a mouse model of retinopathy [27,28] (Table 1). The gene discussed is FZD4; the disease is retinal disorder.