Likewise, miR-221 derived from M2 TAMs promoted cancer cell proliferation in epithelial ovarian cancer (EOC) via suppression of the cyclin-dependent kinase inhibitor 1B (CDKN1B) [49] and aggravates the growth and metastasis of cancer cells in osteosarcoma by targeting SOCS3, which then activates the JAK2/STAT3 pathway [50]. This evidence concerns the gene STAT3 and osteosarcoma.