Therefore, in future studies it will be important to determine the role that Zn2+ plays under different models of hypobaric hypoxia, generating new possibilities to understand HPV processes, along with the identification of possible therapeutic targets such as PKCε, MT, ZIP12, and [Zn2+]i in the mitigation of the exacerbated mechanism of HPV, which is one of the mechanisms that induces the development of pathologies such as hypoxia-induced pulmonary hypertension. This evidence concerns the gene SLC39A12 and pulmonary arterial hypertension.