We also tested the interaction of pairwise combinations of VAL2/SNL1, VAL2/SNL1-PAH, VAL2-CW/SNL1, VAL2-CW/SNL1-PAH, VAL2/SNL3, VAL2/SNL3-PAH, VAL2-CW/SNL3, and VAL2-CW/SNL3-PAH in Y2H assay, and no interaction in the above pairwise combinations was observed (Figure S4A). This evidence concerns the gene PAH and pulmonary arterial hypertension.