Loss of parafibromin has been reported in few cases (0–3.7%) of multiglandular parathyroid disease [38,67,68], 0–17.6% of adenomas [38,39,55,67] and 33.3–100% of parathyroid carcinomas [38,55,67,69] except carcinomas associated with tertiary hyperparathyroidism (0%) as reported by Tominaga et al., 2008 [70]. This evidence concerns the gene CDC73 and adenoma.