Insulinoma-associated protein 1 (INSM1) is absent [140] both from normal and pathological parathyroid tissues including multiglandular parathyroid disease in primary hyperparathyroidism, secondary hyperplasia, tertiary hyperparathyroidism, adenomas, atypical adenomas and carcinomas [140]. This evidence concerns the gene INSM1 and parathyroid gland disorder.