ORAI1 and tubular aggregate myopathy: By contrast, dominant STIM1 and ORAI1 gain-of-function (GoF) mutations induce SOCE overactivity and excessive Ca2+ entry and give rise to tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) (OMIM #160565, #615883), two clinically overlapping disorders associating childhood-onset muscle weakness with miosis, ichthyosis, short stature, hyposplenism, thrombocytopenia, and dyslexia [9,10,11,12,13,14,15,16,17,18].