Conversely, KCNN4-overexpression promoted tumorigenicity and tumor growth, which was indicated by a significantly increased tumor incidence (7/7 vs. 5/7) (Figure 3A, Supplementary Figure S2F) and liver weight (1.88 ± 0.14 vs. 1.46 ± 0.09 g, Figure 3B). This evidence concerns the gene KCNN4 and neoplasm.