KCNN4 and neoplasm: Firstly, in an orthotopic xenograft model of nude mouse, KCNN4-knockdown resulted in a reduction in tumor incidence (1/7 vs. 5/7) (Figure 3A, Supplementary Figure S1H) and loss of liver weight (1.24 ± 0.06 vs. 1.46 ± 0.09 g, Figure 3B).