A dysfunction of the AKT-GSK3β-NRF2 axis is thought to play a role in human neurological disorders, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis and adrenoleukodystrophy [38,39] but also in mood disorders [40]. The gene discussed is GSK3B; the disease is early-onset autosomal dominant Alzheimer disease.