Glycogen synthase kinase 3 (GSK3), a serine/threonine protein kinase that mediates the attachment of phosphate molecules to the amino acid residues of serine and threonine, has been shown to disrupt mitochondrial transport in AD through the phosphorylation and deactivation of mitochondrial transport motor proteins and through increased Tau phosphorylation at AT8 sites [62]. This evidence concerns the gene MAPT and Alzheimer disease.