ITGB3 and Crohn disease: Neovascularization is a feature of IBD, and both angiogenesis with elevated levels of integrin αVβ3 (i.e., ITGAV and ITGB3, expressed by angiogenic endothelium) and inducible levels of angiogenic factors (vascular endothelial growth factor, fibroblast growth factor 2, and interleukin-8) have been demonstrated in inflamed, but not in non-inflamed, colonic mucosa from UC and Crohn’s disease patients [38].