EGFR and non-small cell lung carcinoma: Considering the tropism of the oncogene disease addicted to the diffusion of the brain, the results of the phase 3 study COMPEL (NCT04765059) will be very interesting, evaluating the continuation of osimertinib or placebo with platinum-based chemotherapy in patients with EGFR-mutated metastatic NSCLC who responded to first-line osimertinib therapy and subsequently experienced radiological, extracranial disease progression, with stratification based on the presence or absence of specific endpoint encephalic metastases for CNS outcomes.