High expression of HIF induces the up-regulation of angiogenic factors, such as vascular endothelial growth factor (VEGF), angiopoietin (Ang1 and Ang2), VEGF receptor (VEGFR), and Tie2 receptor at the transcriptional level, thereby, promoting the formation of new blood vessels in cancer [13,14]. This evidence concerns the gene ANGPT2 and cancer.