Its findings largely support the previously published observation that HMGA1 overexpression is a common feature of cancers, even those with distinct tissue origins: tumors of the head and neck, breast, gastrointestinal, and reproductive system, as well as melanoma and lymphomas, demonstrated elevated HMGA1 expression in comparison to non-cancerous tissue, followed by an increase in HMGA1 protein. This evidence concerns the gene HMGA1 and cancer.