For most of these proteins, there is some evidence that they are concerned with neoplastic transformation in the lung. Ribosomal proteins S6 kinase B1 (RPS6KB1, p70S6K) are critical components of mTOR signaling, that have been found to increase the growth of NSCLC cells in vivo and inhibit tumor metastasis through repression of epithelial-mesenchymal transition [36]. The gene discussed is RPS6KB1; the disease is neoplasm.