In a 2008 Cochrane Review of drugs to treat POI, erythromycin (used to treat ileus in the US) was shown to be ineffective for the treatment of ileus and the effects were inconsistent or insufficient evidence was available to recommend any other drugs, including serotonin agonists (cisapride), dopamine antagonists (metoclopramide), beta-blockers (propranolol), vasopressin, or cholecystokinin-like drugs (cerulatide) [19]. The gene discussed is CCK; the disease is ileus.