CASP9 and Zinc deficiency: As it was shown on hearts of weaned piglets affected by subclinical zinc deficiency, the level of glutathione and the expression of ROS-detoxifying enzymes (glutathione, glutathione reductase, catalase and metallothionein 1A) was decreased, while the expression of pro-apoptotic genes (B-cell lymphoma 2–associated X protein (BAX) and caspase 9 (CASP9)) was increased and the expression of (FAS), etoposide-induced 2.4 (EI24) and cyclin-dependent kinase inhibitor 1A (CDKN1A) correlated positively to cardiac zinc level in piglets [12].