PHOX2B and rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome: A later age of onset (median age of 3 years), very dramatic sudden weight gain, and negative PHOX2B genotypic sequencing distinguish ROHHAD from congenital central hypoventilation syndrome (CCHS), which was first reported by Robert Mellins et al. in 1970 [14].