HLA-C and metastatic melanoma: Taken together, our data point at a complete and deep remodelling of protein synthesis and degradation in metastatic melanoma that suggests, alongside biopsy genotyping, a more integrated evaluation of specific gene expression patterns—in particular, those related to MHC, proteasomes, and rProteins—as a practice that could help in choosing the most effective treatment in a context of personalised medicine.