BRAF and melanoma: In order to obtain a comparative transcriptomic profile of melanoma cells relative to the healthy tissue (i.e., non-dysplastic naevi composed of healthy melanocytes representing the normal counterpart of melanoma cells), a pilot study was designed, and we performed a manual microdissection of paraffin-embedded surgical samples [19] of both normal tissue and BRAF wild type melanoma from patients whose clinicopathological characteristics are in Table 1.