BRAF and metastatic melanoma: In addition, even the RNA-Seq data from the TCGA/GTEx databases confirmed such a significant overexpression of all the MHC class I genes (HLA-A, HLA-B, and HLA-C), as well as the MHC class II (HLA-DMA, HLA-DOA, HLA-DPA1, HLA-DQA1, and HLA-DRA), in BRAF-wild type metastatic melanoma compared to healthy skin tissue (Supplementary Figure S3).