Some years later, Lee et al. [8] suggested that the loss of the tumor suppressor KLF6 in HCC and the consequent activation of PTTG1 promoter activity, due to the loss of direct repression, could be another mechanism contributing to the increased proliferation, angiogenesis, and possibly chromosomal instability in HCC. The gene discussed is KLF6; the disease is hepatocellular carcinoma.