Accordingly, PTTG1 is highly expressed in endocrine and non-endocrine malignancies such as pituitary adenoma, astrocytoma, thyroid cancer, breast and ovarian cancer, renal cell carcinoma, lung cancer, colorectal carcinoma, HCC, and leukemia [10,16,17,18,19,20]. This evidence concerns the gene PTTG1 and neoplasm.